Principal Scientist CNS Translational Science

Industry Sector Biotechnology, Pharmaceutical
Location UK, South East
Salary Competitive


Principal Scientist CNS Translational Science


Location – Cambridge


Our client is an early-stage drug development company specializing in the treatment of neurodegenerative disease, rare mitochondrial diseases and fibrosis.  The key research focus is on the discovery and development of first-in-class, small molecule drugs of significant commercial interest.


An opportunity has come available in the Translational Sciences for an experienced Principal Scientist to support in the development of new and effective therapeutics for neurodegenerative diseases through an in-depth knowledge of the cellular, molecular and genetic mechanisms. As a Principal Scientist you will operate in a predominantly laboratory based role and will utilise knowledge of translatable markers/endpoints for use in non-clinical in vivo and in vitro models, to support our lead preclinical program and ongoing pharma collaborations


Key responsibilities of the role will include


·      Identify, validate and develop approaches for prosecuting new drug targets in neurodegenerative diseases.

·      Design and delivery of pharmacology/ pharmacodynamics studies, including ex vivo analysis and translatable cellular assay systems.

·      Develop and implement new translatable in vitro cell model systems including iPSC-derived CNS cell populations. 

·      Oversight and management of ongoing and new/planned studies at both academic and contract research organisations.

·      Contribute CNS pharmacology expertise across pipeline projects.

·      Effective collaboration management.

·      Critically analyse and interpret data, define realistic timelines for studies and meet delivery deadlines.

·      Execute high impact studies within an extremely fast-paced and collaborative environment.

·      Delivery of pharmacology/pharmacodynamics research reports.

·      Support identification and validation of novel therapeutic targets and delivery of new targets into the pipeline.


Qualifications, Skills and Experience


·      Ph.D. in neurology/neuroscience with additional experience in a relevant pharmaceutical industry / postdoctoral position.

·      Experience of studying translational markers/assessments (e.g. e-phys, fluid markers) relevant for CNS indications.

·      Established scientific reputation in the field of neurodegenerative diseases, in particular Parkinson’s Disease, as evidenced by publication track record.

·      Deep expertise in cell biology and genetics underlying neurodegenerative diseases, in particular Parkinson’s Disease, with knowledge of the drug discovery/development space in this area a plus.

·      Practical experience investigating one or more of the following areas in vivo: mitochondrial dysfunction, protein mis-folding and aggregation, protein spreading and seeding, cellular proteostasis mechanisms, neuroinflammation.

·      Excellent cell biology and western blotting skills including antibody validation for westerns and ELISAs.

·      Practical experience with CNS cell populations and iPSC-derived cells.

·      Experience working in cross-functional and matrixed Research and Translational teams is highly desirable

·      Use of relevant in vitro and in vivo models and experience of working with CROs to deliver in vitro and in vivo studies.

·      Able to establish, maintain and manage effective collaborations with external partners.

·      Excellent communication skills at both detailed and summarised levels.

·      Team player with ability to conduct independent research.

·      Able to quickly prioritise deliverables according to team and business requirements.


In return, my client offers a competitive salary and an opportunity to work in an innovative company within the heart of the UK Science Sector.

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