Translational Research Scientist – Renal Cell Biology

Description

Translational Research Scientist – Renal Cell Biology

Location – Cambridge

Duration – 12 month FTC

Our client is an early-stage drug development company specializing in the treatment of neurodegenerative disease, rare mitochondrial diseases and fibrosis.  The key research focus is on the discovery and development of first-in-class, small molecule drugs of significant commercial interest.

This opportunity is for an initial 12 month contract and will be working within the companies Translational Sciences team supporting the pre-clinical program through study of quantitative and mechanistic effects of small molecule drug candidates on renal cell biology and mitochondria.

Key responsibilities of the role will include

• Design and delivery of pharmacology / pharmacodynamics studies, including ex vivo analysis and use of translatable cellular assay systems.
• Develop and implement new translatable in vivo and in vitro cell model systems and biochemical assay methods for renal injury / fibrosis.
• Input to- and management of- ongoing and new/planned studies at both academic and contract research organisations.
• Critically analyse and interpret data, define realistic timelines for studies and meet delivery deadlines.
• Execute high impact studies within an extremely fast-paced and collaborative environment.
• Contribute cell biology, metabolism and bioenergetics expertise across pipeline projects.
• Effective collaboration management.
• Delivery of pharmacology/pharmacodynamics research reports and presentations.

Qualifications, Skills and Experience

• Ph.D. in renal disease or mitochondrial biology and bioenergetics with additional experience within a relevant pharmaceutical industry role or postdoctoral experience.
• Experience of studying translational markers/assessments in cell systems and in ex vivo tissues from preclinical models.
• Established scientific reputation as evidenced by publication track record.
• Practical experience investigating one or more of the following areas in vitro / ex vivo: mitochondrial dysfunction, protein mis-folding and aggregation, cellular proteostasis mechanisms, metabolomics.
• Excellent cell biology and western blotting skills including antibody validation for westerns and ELISAs.
• Practical experience with primary renal cell populations is desirable.
• Experience working in cross-functional and matrixed Research and Translational teams is desirable.
• Use of relevant in vitro and in vivo models and experience of working with CROs to deliver in vitro and in vivo studies.
• Able to establish, maintain and manage effective collaborations with external partners.
• Excellent communication skills at both detailed and summarised levels.
• Team player with ability to conduct independent research.
• Able to quickly prioritise deliverables according to team and business requirements.
• Excellent communication skills at both detailed and summarised levels.
• Team player with ability to conduct independent research.
• Able to quickly prioritise deliverables according to team and business requirements.

In return, my client offers a competitive salary and an opportunity to work in an innovative company within the heart of the UK Science Sector.