Upstream Development Scientist

Industry Sector Biotechnology
Location UK, South East
Salary Competitive


Upstream Development Scientist   

Location - Oxfordshire


Our client is an Oxfordshire based biotechnology company who specialise in novel approaches to drug targeting and delivery to support a new class of therapeutics.


Due to continued company growth our client is now seeking and experience Scientist to join the Process Development team and support with Upstream Process Development.


The role:

Working within the Process Development the primary focus of the role is to support the development of Upstream processing through:


  • Optimisation of mammalian cell culture in batch, fed batch and perfusion process
  • Effective cell culture from small-scale to process scale up (from 2L to 200L performance)
  • Support of routine analytical testing (SDS Page, W.Blotting, Biochemical Assays and ELISA)
  • Support in Technology Transfer
  • Work in close collaboration with other internal departments to continually progress process development
  • Ensure work is compliant with GMO/ACDP requirements


Suitable applicants:

This position would suit an ambitious and motivated scientist looking to utilise and build-upon their experience within Upstream Process Development.

Key Experience includes:


  • PhD in a relevant discipline (or BSc/MSc plus equivalent experience) with industry experience in process development
  • Proven industry experience in mammalian cell culture, process development and scale-up, ideally within proteins or viral products
  • Familiar with bioreactor systems
  • Experience with basal medium, feed development and optimisation
  • Experience with the development of perfusion process would be beneficial
  • Familiar with in-process analytical methods for mammalian cell culture


The Package:

In return, my client offers an opportunity to join the company on a permanent basis with an attractive salary and company benefits.


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